B-1053: Piscine orthoreovirus: Distribution, characterization and experimental infection in salmonids (joint WAVMA+EAFP WebCEPD)

More about this event

This WebCEPD in organized in partnership with the European Association of Fish Pathologists.

Presentation Synopsis: 

Piscine Orthoreovirus have Piscine Orthoreovirus genotype 3 (PRV-3) was firstly discovered in 2013 in Norway during disease outbreaks affecting farmed Rainbow trout. The first series of experimental trials were performed to assess its pathogenicity and pathogenesis in Rainbow trout and Atlantic salmon.

This isolate has been further characterized analyzing its genome and antigenic features. An experimental infection study with purified virus demonstrated that PRV-3 infection in Rainbow trout induces pathological heart lesions similar to HSMI, and thus fulfil causative relationship. Furthermore, the infection upregulates IFN production and induces a specific antibody response in later phases.

In late 2017 the presence of PRV-3 was also reported in different countries. Interestingly, these viral isolates appear to be genetically distinct from the Norwegian isolate leading to the proposition of two separate clades within PRV-3 viral type (PRV-3a and PRV-3b). Further insights of the role of PRV-3 in complex disease case will be given in the presentation.

Presentation Learning Objectives:

1. Review the current knowledge on PRVs in salmonids
2. Understand concepts of pathogenesis experimental infection trials with uncultivable viruses
3. Review criteria to define disease and its causative agent

Speaker Bio:

DVM University of Padova 2009. Since 2012 coordinator of European Reference Laboratory for fish diseases – at Technical University of Denmark, DTU, first at DTU-Vet, National Veterinary Institute, then at DTU Aqua – National institute of Aquatic Resources. PhD in Fish Virology in 2019. In 2019, De Facto Member of European College of Aquatic Animal Health. Since 2020 researcher at Unit for fish and Shellfish diseases at DTU Aqua.